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1

Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges

Journal:

Year:

2009

Language:

english

File:

PDF, 287 KB

english, 2009

2

Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistance

Wenlin Shao, Joseph D. Growney, Yun Feng, Gregory O'Connor, Minying Pu, Wenjing Zhu, Yung-Mae Yao, Paul Kwon, Stephen Fawell, Peter Atadja

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 567 KB

english, 2010

3

Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat

Ben P. Martin, Ailsa J. Frew, Michael Bots, Stephen Fox, Fenella Long, Kazuyoshi Takeda, Hideo Yagita, Peter Atadja, Mark J. Smyth, Ricky W. Johnstone

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 716 KB

english, 2011

4

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Lewis Whitehead, Markus R. Dobler, Branko Radetich, Yanyi Zhu, Peter W. Atadja, Tavina Claiborne, Jonathan E. Grob, Andrew McRiner, Margaret R. Pancost, Anup Patnaik, Wenlin Shao, Michael Shultz, Rite

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

5

The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines

Michael B Prystowsky, Alfred Adomako, Richard V Smith, Nicole Kawachi, Wendy McKimpson, Peter Atadja, Quan Chen, Nicolas F Schlecht, Joanna L Parish, Geoffrey Childs, Thomas J Belbin

Journal:

The Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 367 KB

english, 2009

6

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

Villagra, Alejandro, Cheng, Fengdong, Wang, Hong-Wei, Suarez, Ildelfonso, Glozak, Michelle, Maurin, Michelle, Nguyen, Danny, Wright, Kenneth L, Atadja, Peter W, Bhalla, Kapil

Journal:

Nature Immunology

Year:

2008

Language:

english

File:

PDF, 521 KB

english, 2008

7

Erratum: The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

Villagra, Alejandro, Cheng, Fengdong, Wang, Hong-Wei, Suarez, Ildelfonso, Glozak, Michelle, Maurin, Michelle, Nguyen, Danny, Wright, Kenneth L, Atadja, Peter W, Bhalla, Kapil

Journal:

Nature Immunology

Year:

2009

Language:

english

File:

PDF, 81 KB

english, 2009

8

PSC-833, a frontier in modulation of P-glycoprotein mediated multidrug resistance

Peter Atadja, Toru Watanabe, Hong Xu, Dalia Cohen

Journal:

Cancer and Metastasis Reviews

Year:

1998

File:

PDF, 434 KB

1998

9

Differential effects of transforming growth factor-β1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts

Dylan R. Edwards, Kevin J. Leco, Paul P. Beaudry, Peter W. Atadja, Claude Veillette, Karl T. Riabowol

Journal:

Experimental Gerontology

Year:

1996

Language:

english

File:

PDF, 1.35 MB

english, 1996

10

Detecting S-adenosyl-l-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay

Ying Lin, Hong Fan, Mathias Frederiksen, Kehao Zhao, Lei Jiang, Zhaofu Wang, Shaolian Zhou, Weihui Guo, Jun Gao, Shu Li, Edmund Harrington, Peter Meier, Clemens Scheufler, Yao-Chang Xu, Peter Atadja,

Journal:

Analytical Biochemistry

Year:

2012

Language:

english

File:

PDF, 916 KB

english, 2012

11

In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors

Angela Brieger, Simone Boehrer, Simone Schaaf, Daniel Nowak, Martin Ruthardt, Soo-Zin Kim, Peter Atadja, Dieter Hoelzer, Paris S Mitrou, Eckhart Weidmann, Kai Uwe Chow

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 427 KB

english, 2004

12

Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells

Piergiorgio Pettazzoni, Stefania Pizzimenti, Cristina Toaldo, Paula Sotomayor, Luigina Tagliavacca, Song Liu, Dan Wang, Rosalba Minelli, Leigh Ellis, Peter Atadja, Eric Ciamporcero, Mario Umberto Dian

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

13

Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma

Martin Kaiser, Britta Lamottke, Maren Mieth, Michael R. Jensen, Cornelia Quadt, Carlos Garcia-Echeverria, Peter Atadja, Ulrike Heider, Ivana Von Metzler, Seval Türkmen, Orhan Sezer

Journal:

European Journal of Haematology

Year:

2010

Language:

english

File:

PDF, 278 KB

english, 2010

14

Overexpression of Cyclin D1 Blocks Proliferation of Normal Diploid Fibroblasts

Peter Atadja, Howard Wong, Claude Veillete, Karl Riabowol

Journal:

Experimental Cell Research

Year:

1995

File:

PDF, 1.22 MB

1995

15

Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: Potential role of histone deacetylase 6

In Ah Kim, Mina No, Jang Mi Lee, Jin Hee Shin, Jee Sun Oh, Eun Jung Choi, Il Han Kim, Peter Atadja, Eric J. Bernhard

Journal:

Radiotherapy and Oncology

Year:

2009

Language:

english

File:

PDF, 710 KB

english, 2009

16

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of a Novel Histone Deacetylase Inhibitor, LAQ824, in Human Colon Carcinoma Cells and Xenografts

Chung, Yuen-Li, Troy, Helen, Kristeleit, Rebecca, Aherne, Wynne, Jackson, L. Elizabeth, Atadja, Peter, Griffiths, John R., Judson, Ian R., Workman, Paul, Leach, Martin O., Beloueche-Babari, Mounia

Journal:

Year:

2008

Language:

english

File:

PDF, 624 KB

english, 2008

17

Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

Cao, Fang, Townsend, Elizabeth C., Karatas, Hacer, Xu, Jing, Li, Li, Lee, Shirley, Liu, Liu, Chen, Yong, Ouillette, Peter, Zhu, Jidong, Hess, Jay L., Atadja, Peter, Lei, Ming, Qin, Zhaohui S., Malek,

Journal:

Year:

2014

Language:

english

File:

PDF, 3.55 MB

english, 2014

18

Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates

Remiszewski, Stacy W., Sambucetti, Lidia C., Atadja, Peter, Bair, Kenneth W., Cornell, Wendy D., Green, Michael A., Howell, Kobporn Lulu, Jung, Manfred, Kwon, Paul, Trogani, Nancy, Walker, Heather

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 242 KB

english, 2002

19

Absolute Quantification of Histone PTM Marks by MRM-Based LC-MS/MS

Gao, Jun, Liao, Rijing, Yu, Yanyan, Zhai, Huili, Wang, Yingqi, Sack, Ragna, Peters, Antoine H. F. M., Chen, Jiajia, Wu, Haiping, Huang, Zheng, Hu, Min, Qi, Wei, Lu, Chris, Atadja, Peter, Oyang, Counde

Journal:

Analytical Chemistry

Year:

2014

Language:

english

File:

PDF, 1.64 MB

english, 2014

20

Regulation of transcription factor activity during cellular aging

Wheaton, Keith, Atadja, Peter, Riabowol, Karl

Journal:

Biochemistry and Cell Biology

Year:

1996

Language:

english

File:

PDF, 1.71 MB

english, 1996

21

Increased Activity of p53 in Senescing Fibroblasts

Peter Atadja, Howard Wong, Igor Garkavtsev, Claude Veillette and Karl Riabowol

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.29 MB

english, 1995

22

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia

Salmon, Jessica M, Bots, Michael, Vidacs, Eva, Stanley, Kym L, Atadja, Peter, Zuber, Johannes, Johnstone, Ricky W

Journal:

Clinical Epigenetics

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

23

The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity

Woods, David M., Woan, Karrune, Cheng, Fengdong, Wang, Hongwei, Perez-Villarroel, Patricio, Lee, Calvin, Lienlaf, Maritza, Atadja, Peter, Seto, Edward, Weber, Jeffrey, Sotomayor, Eduardo M., Villagra,

Journal:

Melanoma Research

Year:

2013

Language:

english

File:

PDF, 614 KB

english, 2013

24

Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells

Fiskus, Warren, Buckley, Kate, Rao, Rekha, Mandawat, Aditya, Yang, Yonghua, Joshi, Rajeshree, Wang, Yongchao, Balusu, Ramesh, Chen, Jianguang, Koul, Sanjay, Joshi, Atul, Upadhyay, Sunil, Atadja, Peter

Journal:

Cancer Biology & Therapy

Year:

2009

Language:

english

File:

PDF, 2.17 MB

english, 2009

25

SetDB1 modulates PRC2 activity at developmental genes independent of H3K9 trimethylation in mouse ES cells

Fei, Qi, Yang, Xiaoqin, Jiang, Hua, Wang, Qian, Yu, Yanyan, Yu, Yiling, Yi, Wei, Zhou, Shaolian, Chen, Taiping, Lu, Chris, Atadja, Peter, Liu, Xiaole Shirley, Li, En, Zhang, Yong, Shou, Jianyong

Journal:

Genome Research

Year:

2015

Language:

english

File:

PDF, 7.79 MB

english, 2015

26

Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation

Zhou, Qun, Atadja, Peter, Davidson, Nancy E.

Journal:

Cancer Biology & Therapy

Year:

2007

Language:

english

File:

PDF, 891 KB

english, 2007

27

Current trends in outwitting resistance development in Candida infections through photodynamic and short peptide therapies: a strategic-shift from conventional antifungal agents

Bengyella, louis, Waikhom, Sayanika Devi, Atadja, Peter W.

Journal:

Expert Review of Anti-infective Therapy

Year:

2016

Language:

english

File:

PDF, 991 KB

english, 2016

28

Loss of Serum Response Factor Activity Is the Basis of Reduced C-FOS Expression in Aging Human Fibroblasts

Atadja, Peter W., Riabowol, Karl T.

Journal:

Canadian Journal on Aging

Year:

1996

Language:

english

File:

PDF, 2.95 MB

english, 1996

29

Histone deacetylase inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-related pathway.

Rosato, Roberto R., Kolla, Sarah S., Hock, Stefanie K., Almenara, Jorge A., Patel, Ankita, Amin, Sanjay, Atadja, Peter, Fisher, Paul B., Dent, Paul, Grant, Steven

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 49 KB

english, 2016

30

Histone Demethylase LSD1 Promotes Adipocyte Differentiation through Repressing Wnt Signaling

Chen, Yan, Kim, Jeesun, Zhang, Ruipeng, Yang, Xiaoqin, Zhang, Yong, Fang, Jianwu, Chen, Zhui, Teng, Lin, Chen, Xiaowei, Ge, Hui, Atadja, Peter, Li, En, Chen, Taiping, Qi, Wei

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 3.85 MB

english, 2016

31

HDAC inhibitor panobinostat engages host innate immune defenses to promote the tumoricidal effects of trastuzumab in HER2+ tumors

Medon, Mikolaj, Vidacs, Eva, Vervoort, Stephin J, Li, Jason, Jenkins, Misty R, Ramsbottom, Kelly M, Trapani, Joseph A, Smyth, Mark J., Darcy, Phillip K., Atadja, Peter W, Henderson, Michael A, Johnsto

Journal:

Cancer Research

Year:

2017

Language:

english

File:

PDF, 645 KB

english, 2017

32

A Histone Deacetylase Inhibitor LBH589 Downregulates XIAP in Mesothelioma Cell Lines Which is Likely Responsible for Increased Apoptosis With TRAIL

Symanowski, James, Vogelzang, Nicholas, Zawel, Leigh, Atadja, Peter, Pass, Harvey, Sharma, Sunil

Journal:

Journal of Thoracic Oncology

Year:

2009

Language:

english

File:

PDF, 1.35 MB

english, 2009

33

Regulation of Gene Expression and Transcription Factor Binding Activity during Cellular Aging

Meyyappan, Muthupalaniappan, Atadja, Peter W., Riabowol, Karl T.

Journal:

Year:

1996

Language:

english

File:

PDF, 1.44 MB

english, 1996

34

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain

Senisterra, Guillermo, Zhu, Hugh Y., Luo, Xiao, Zhang, Hailong, Xun, Guoliang, Lu, Chunliang, Xiao, Wen, Hajian, Taraneh, Loppnau, Peter, Chau, Irene, Li, Fengling, Allali-Hassani, Abdellah, Atadja, P

Journal:

Year:

2018

Language:

english

File:

PDF, 2.03 MB

english, 2018

35

Polycomb Target Genes Are Silenced in Multiple Myeloma

Kalushkova, Antonia, Fryknäs, Mårten, Lemaire, Miguel, Fristedt, Charlotte, Agarwal, Prasoon, Eriksson, Maria, Deleu, Sarah, Atadja, Peter, Österborg, Anders, Nilsson, Kenneth, Vanderkerken, Karin, Öb

Journal:

Year:

2010

Language:

english

File:

PDF, 1.91 MB

english, 2010

36

Involvement of Histone Acetylation of Sox17 and Foxa2 Promoters during Mouse Definitive Endoderm Differentiation Revealed by MicroRNA Profiling

Fu, Shijun, Fei, Qi, Jiang, Hua, Chuai, Shannon, Shi, Song, Xiong, Wen, Jiang, Lei, Lu, Chris, Atadja, Peter, Li, En, Shou, Jianyong, Cooney, Austin John

Journal:

Year:

2011

Language:

english

File:

PDF, 874 KB

english, 2011

37

Concurrent HDAC and mTORC1 Inhibition Attenuate Androgen Receptor and Hypoxia Signaling Associated with Alterations in MicroRNA Expression

Ellis, Leigh, Lehet, Kristin, Ramakrishnan, Swathi, Adelaiye, Remi, Miles, Kiersten M., Wang, Dan, Liu, Song, Atadja, Peter, Carducci, Michael A., Pili, Roberto, Schneider, Guenter

Journal:

Year:

2011

Language:

english

File:

PDF, 4.11 MB

english, 2011

38

ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth

Thakur, Satbir, Feng, Xiaolan, Qiao Shi, Zhong, Ganapathy, Amudha, Kumar Mishra, Manoj, Atadja, Peter, Morris, Don, Riabowol, Karl, Katz, Elad

Journal:

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

39

FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

Fan, Yichao, Yue, Jiao, Xiao, Mengtao, Han-Zhang, Han, Wang, Yao Vickie, Ma, Chun, Deng, Zhilin, Li, Yingxiang, Yu, Yanyan, Wang, Xinghao, Niu, Shen, Hua, Youjia, Weng, Zhiping, Atadja, Peter, Li, En,

Journal:

Year:

2017

Language:

english

File:

PDF, 5.44 MB

english, 2017

40

Correction to: Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia

Salmon, Jessica M., Bots, Michael, Vidacs, Eva, Stanley, Kym L., Atadja, Peter, Zuber, Johannes, Johnstone, Ricky W.

Journal:

Clinical Epigenetics

Year:

2020

File:

PDF, 4.14 MB

2020